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ODT formulations may have different side effect profiles since they bypass the stomach, but without clinical data, this remains theoretical

Altered gut microbiota in individuals with episodic and chronic migraine

10.1021/acs.chemrev.5b00484 15 ChenZ.-S.Hopper-BorgeE.BelinskyM

Notably, obesity and joint injury remain the most prominent modifiable risk factors, whereas age, sex, and genetic predisposition are considered non-modifiable contributors (Figure 2) (Nedunchezhiyan et al., 2022